Quatrefolic® Superior to Folic Acid for Recurrent Miscarriages

A published case series study has evaluated the effect of Quatrefolic® in couples with recurrent miscarriages, lasting for at least 4 years.

5-MTHF glucosamine salt (Quatrefolic®) has been trialled in a B vitamin complex and chelated zinc at the dosage of 800 mcg/day.


800mcg Quatrefolic® vs 5mg of folic acid

The study conclusion highlights that the conventional use of large doses of folic acid (5 mg/day) has become obsolete. A physiological dose of 5-MTHF glucosamine salt (800 mcg) bypasses the MTHFR block and is suggested to be an effective treatment for couple fertility problems (recurrent miscarriages).

In the trial, the selected population shows a strong link between an impaired folate cycle, due to the presence of polymorphism of the enzyme methylenetetrahydrofolate reductase (MTHFR).  Consequently the capacity to achieve conception and carry a pregnancy to term.

Most of the women had been previously treated unsuccessfully with high doses of folic acid (5 mg/day).  Of 33 couples, 13 spontaneous pregnancies were observed at the end of the treatment.  Another 13 pregnancies were obtained after Assisted Reproductive Technology (ART). An overall ongoing pregnancy rate of 86.7%.


Unmetabolised folic acid syndrome

Supplementation with 5-MTHF (Quatrefolic®) instead of folic acid appears to be an effective treatment for patients carrying the above mutations. The physiological dose of 5-MTHF glucosamine salt (800mcg) bypasses the MTHFR block.

On the contrary, excess of folic acid intake leads to the UMFA (Unmetabolised Folic Acid) syndrome in this peculiar population; UMFA syndrome may increase cancer risks and cause immune dysfunction.


Efficacy and safety

This study highlights the benefits of Quatrefolic® – the active folate form immediately available without metabolisation of MTHFR enzyme.  Finished formulations with Quatrefolic® are in the limelight of new clinical studies, providing even more evidence of the real advantages over folic acid, in terms of efficacy and safety.


NaturoBest Prenatal Trimester One contains 500mcg of Quatrefolic in a daily dose!


Ref: Servy, E.J., Jacquesson-Fournols, L., Cohen, M. et al. MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series. J Assist Reprod Genet 2018.


Quatrefolic® Superior to Folic Acid for Recurrent Miscarriages